منابع مشابه
Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening**
The widespread application of ω-transaminases as biocatalysts for chiral amine synthesis has been hampered by fundamental challenges, including unfavorable equilibrium positions and product inhibition. Herein, an efficient process that allows reactions to proceed in high conversion in the absence of by-product removal using only one equivalent of a diamine donor (ortho-xylylenediamine) is repor...
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Amine transaminases are enzymes that catalyze the mild and selective formation of primary amines, which are useful building blocks for biologically active compounds and natural products. In order to make the production of these kinds of compounds more efficient from both a practical and an environmental point of view, amine transaminases were incorporated into multi-step one-pot reactions. With...
متن کاملIdentification, characterization and application of novel (R)-selective amine transaminases
Modern tools for enzyme discovery andprotein engineering substantially broadened thenumber of enzymes applicable for biocatalysis andhelped to alter their properties such as substraterange, enantioselectivity, and stability under processconditions. In addition, these methods also enabledone to explore reactions for organic synthesis forwhich no suitable enzymes were ...
متن کاملSynergistic Cu-amine catalysis for the enantioselective synthesis of chiral cyclohexenones.
An unprecedented utilization of 1,3-acetonedicarboxylic acid as a 1,3-bis-pro-nucleophile and a reactive acetone surrogate in enantioselective catalysis has been reported. By synergistically activating the ketodiacid by copper catalysis and an α,β-unsaturated aldehyde by amine catalysis, an efficient domino di-decarboxylative Michael/aldol/dehydration sequence takes place leading to valuable ch...
متن کاملA new target region for changing the substrate specificity of amine transaminases
(R)-stereospecific amine transaminases (R-ATAs) are important biocatalysts for the production of (R)-amine compounds in a strict stereospecific manner. An improved R-ATA, ATA-117-Rd11, was successfully engineered for the manufacture of sitagliptin, a widely used therapeutic agent for type-2 diabetes. The effects of the individual mutations, however, have not yet been demonstrated due to the lac...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2018
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2017.12.007